A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults-study design and baseline characteristics of the FINGER-NL randomized controlled trial (2024)

MOCIA consortium, Deckers, K., Zwan, M. D., Soons, L. M., Waterink, L., Beers, S., van Houdt, S., Stiensma, B., Kwant, J. Z., Wimmers, S. C. P. M., Heutz, R. A. M., Claassen, J. A. H. R., Oosterman, J. M., de Heus, R. A. A., van de Rest, O., Vermeiren, Y., Voshaar, R. C. O., Smidt, N., Broersen, L. M., ... van der Flier, W. M. (2024). A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults-study design and baseline characteristics of the FINGER-NL randomized controlled trial. , 16(1), Article 126. https://doi.org/10.1186/s13195-024-01495-8

MOCIA consortium ; Deckers, Kay ; Zwan, Marissa D et al. / A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults-study design and baseline characteristics of the FINGER-NL randomized controlled trial. In: . 2024 ; Vol. 16, No. 1.

@article{8ef34840865945caa8aaa59b2df2809a,

title = "A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults-study design and baseline characteristics of the FINGER-NL randomized controlled trial",

abstract = "BACKGROUND: Evidence on the effectiveness of multidomain lifestyle interventions to prevent cognitive decline in older people without dementia is mixed. Embedded in the World-Wide FINGERS initiative, FINGER-NL aims to investigate the effectiveness of a 2-year multidomain lifestyle intervention on cognitive functioning in older Dutch at risk individuals.METHODS: Multi-center, randomized, controlled, multidomain lifestyle intervention trial with a duration of 24 months. 1210 adults between 60-79 years old with presence of ≥ 2 modifiable risk factors and ≥ 1 non-modifiable risk factor for cognitive decline were recruited between January 2022 and May 2023 via the Dutch Brain Research Registry and across five study sites in the Netherlands. Participants were randomized to either a high-intensity or a low-intensity intervention group. The multidomain intervention comprises a combination of 7 lifestyle components (physical activity, cognitive training, cardiovascular risk factor management, nutritional counseling, sleep counseling, stress management, and social activities) and 1 nutritional product (Souvenaid{\textregistered}) that could help maintain cognitive functioning. The high-intensity intervention group receives a personalized, supervised and hybrid intervention consisting of group meetings (on-site and online) and individual sessions guided by a trained lifestyle coach, and access to a digital intervention platform that provides custom-made training materials and selected lifestyle apps. The low-intensity intervention group receives bi-monthly online lifestyle-related health advice via the digital intervention platform. Primary outcome is 2-year change on a cognitive composite score covering processing speed, executive function, and memory.RESULTS: Within 17 months, participant recruitment has been successfully completed (N = 1210; mean age: 67.7 years (SD: 4.6); 64% female). Modifiable risk factors commonly present at baseline were physical inactivity (89%), low mental/cognitive activity (50%), low social engagement (39%), hypertension (39%) and high alcohol consumption (39%). The mean body mass index of participants was 28.3 (SD: 4.2) and the total serum cholesterol was 5.4 mmol/L (SD: 1.2).CONCLUSIONS: Baseline lifestyle and clinical measurements showed successful recruitment of participants with sufficient potential for prevention. Results of FINGER-NL will provide further insight into the efficacy of a multidomain lifestyle intervention to prevent cognitive decline in older adults.TRIAL REGISTRATION: ClinicalTrials.gov (ID: NCT05256199)/2022-01-11.",

keywords = "Humans, Aged, Female, Male, Netherlands, Middle Aged, Life Style, Cognitive Dysfunction/prevention & control, Cognition/physiology, Exercise/physiology, Risk Factors, Risk Reduction Behavior",

author = "{MOCIA consortium} and Kay Deckers and Zwan, {Marissa D} and Soons, {Lion M} and Lisa Waterink and Sonja Beers and {van Houdt}, Sofie and Berrit Stiensma and Kwant, {Judy Z} and Wimmers, {Sophie C P M} and Heutz, {Rachel A M} and Claassen, {Jurgen A H R} and Oosterman, {Joukje M} and {de Heus}, {Rianne A A} and {van de Rest}, Ondine and Yannick Vermeiren and Voshaar, {Richard C Oude} and Nynke Smidt and Broersen, {Laus M} and Sikkes, {Sietske A M} and Esther Aarts and Sebastian K{\"o}hler and {van der Flier}, {Wiesje M}",

note = "{\textcopyright} 2024. The Author(s).",

year = "2024",

month = jun,

day = "13",

doi = "10.1186/s13195-024-01495-8",

language = "English",

volume = "16",

journal = "Alzheimers research & therapy",

issn = "1758-9193",

publisher = "BioMed Central Ltd.",

number = "1",

}

MOCIA consortium, Deckers, K, Zwan, MD, Soons, LM, Waterink, L, Beers, S, van Houdt, S, Stiensma, B, Kwant, JZ, Wimmers, SCPM, Heutz, RAM, Claassen, JAHR, Oosterman, JM, de Heus, RAA, van de Rest, O, Vermeiren, Y, Voshaar, RCO, Smidt, N, Broersen, LM, Sikkes, SAM, Aarts, E, Köhler, S & van der Flier, WM 2024, 'A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults-study design and baseline characteristics of the FINGER-NL randomized controlled trial', , vol. 16, no. 1, 126. https://doi.org/10.1186/s13195-024-01495-8

A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults-study design and baseline characteristics of the FINGER-NL randomized controlled trial. / MOCIA consortium; Deckers, Kay; Zwan, Marissa D et al.
In: , Vol. 16, No. 1, 126, 13.06.2024.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults-study design and baseline characteristics of the FINGER-NL randomized controlled trial

AU - MOCIA consortium

AU - Deckers, Kay

AU - Zwan, Marissa D

AU - Soons, Lion M

AU - Waterink, Lisa

AU - Beers, Sonja

AU - van Houdt, Sofie

AU - Stiensma, Berrit

AU - Kwant, Judy Z

AU - Wimmers, Sophie C P M

AU - Heutz, Rachel A M

AU - Claassen, Jurgen A H R

AU - Oosterman, Joukje M

AU - de Heus, Rianne A A

AU - van de Rest, Ondine

AU - Vermeiren, Yannick

AU - Voshaar, Richard C Oude

AU - Smidt, Nynke

AU - Broersen, Laus M

AU - Sikkes, Sietske A M

AU - Aarts, Esther

AU - Köhler, Sebastian

AU - van der Flier, Wiesje M

N1 - © 2024. The Author(s).

PY - 2024/6/13

Y1 - 2024/6/13

N2 - BACKGROUND: Evidence on the effectiveness of multidomain lifestyle interventions to prevent cognitive decline in older people without dementia is mixed. Embedded in the World-Wide FINGERS initiative, FINGER-NL aims to investigate the effectiveness of a 2-year multidomain lifestyle intervention on cognitive functioning in older Dutch at risk individuals.METHODS: Multi-center, randomized, controlled, multidomain lifestyle intervention trial with a duration of 24 months. 1210 adults between 60-79 years old with presence of ≥ 2 modifiable risk factors and ≥ 1 non-modifiable risk factor for cognitive decline were recruited between January 2022 and May 2023 via the Dutch Brain Research Registry and across five study sites in the Netherlands. Participants were randomized to either a high-intensity or a low-intensity intervention group. The multidomain intervention comprises a combination of 7 lifestyle components (physical activity, cognitive training, cardiovascular risk factor management, nutritional counseling, sleep counseling, stress management, and social activities) and 1 nutritional product (Souvenaid®) that could help maintain cognitive functioning. The high-intensity intervention group receives a personalized, supervised and hybrid intervention consisting of group meetings (on-site and online) and individual sessions guided by a trained lifestyle coach, and access to a digital intervention platform that provides custom-made training materials and selected lifestyle apps. The low-intensity intervention group receives bi-monthly online lifestyle-related health advice via the digital intervention platform. Primary outcome is 2-year change on a cognitive composite score covering processing speed, executive function, and memory.RESULTS: Within 17 months, participant recruitment has been successfully completed (N = 1210; mean age: 67.7 years (SD: 4.6); 64% female). Modifiable risk factors commonly present at baseline were physical inactivity (89%), low mental/cognitive activity (50%), low social engagement (39%), hypertension (39%) and high alcohol consumption (39%). The mean body mass index of participants was 28.3 (SD: 4.2) and the total serum cholesterol was 5.4 mmol/L (SD: 1.2).CONCLUSIONS: Baseline lifestyle and clinical measurements showed successful recruitment of participants with sufficient potential for prevention. Results of FINGER-NL will provide further insight into the efficacy of a multidomain lifestyle intervention to prevent cognitive decline in older adults.TRIAL REGISTRATION: ClinicalTrials.gov (ID: NCT05256199)/2022-01-11.

AB - BACKGROUND: Evidence on the effectiveness of multidomain lifestyle interventions to prevent cognitive decline in older people without dementia is mixed. Embedded in the World-Wide FINGERS initiative, FINGER-NL aims to investigate the effectiveness of a 2-year multidomain lifestyle intervention on cognitive functioning in older Dutch at risk individuals.METHODS: Multi-center, randomized, controlled, multidomain lifestyle intervention trial with a duration of 24 months. 1210 adults between 60-79 years old with presence of ≥ 2 modifiable risk factors and ≥ 1 non-modifiable risk factor for cognitive decline were recruited between January 2022 and May 2023 via the Dutch Brain Research Registry and across five study sites in the Netherlands. Participants were randomized to either a high-intensity or a low-intensity intervention group. The multidomain intervention comprises a combination of 7 lifestyle components (physical activity, cognitive training, cardiovascular risk factor management, nutritional counseling, sleep counseling, stress management, and social activities) and 1 nutritional product (Souvenaid®) that could help maintain cognitive functioning. The high-intensity intervention group receives a personalized, supervised and hybrid intervention consisting of group meetings (on-site and online) and individual sessions guided by a trained lifestyle coach, and access to a digital intervention platform that provides custom-made training materials and selected lifestyle apps. The low-intensity intervention group receives bi-monthly online lifestyle-related health advice via the digital intervention platform. Primary outcome is 2-year change on a cognitive composite score covering processing speed, executive function, and memory.RESULTS: Within 17 months, participant recruitment has been successfully completed (N = 1210; mean age: 67.7 years (SD: 4.6); 64% female). Modifiable risk factors commonly present at baseline were physical inactivity (89%), low mental/cognitive activity (50%), low social engagement (39%), hypertension (39%) and high alcohol consumption (39%). The mean body mass index of participants was 28.3 (SD: 4.2) and the total serum cholesterol was 5.4 mmol/L (SD: 1.2).CONCLUSIONS: Baseline lifestyle and clinical measurements showed successful recruitment of participants with sufficient potential for prevention. Results of FINGER-NL will provide further insight into the efficacy of a multidomain lifestyle intervention to prevent cognitive decline in older adults.TRIAL REGISTRATION: ClinicalTrials.gov (ID: NCT05256199)/2022-01-11.

KW - Humans

KW - Aged

KW - Female

KW - Male

KW - Netherlands

KW - Middle Aged

KW - Life Style

KW - Cognitive Dysfunction/prevention & control

KW - Cognition/physiology

KW - Exercise/physiology

KW - Risk Factors

KW - Risk Reduction Behavior

U2 - 10.1186/s13195-024-01495-8

DO - 10.1186/s13195-024-01495-8

M3 - Article

C2 - 38872204

SN - 1758-9193

VL - 16

JO - Alzheimers research & therapy

JF - Alzheimers research & therapy

IS - 1

M1 - 126

ER -

MOCIA consortium, Deckers K, Zwan MD, Soons LM, Waterink L, Beers S et al. A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults-study design and baseline characteristics of the FINGER-NL randomized controlled trial. . 2024 Jun 13;16(1):126. doi: 10.1186/s13195-024-01495-8